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    yet these drugs are not a "home run," says elizabeth loder, md, a professor of neurology at harvard medical school and chief of the division of headache at brigham & women's hospital. .: "evidence for decreased calcitonin gene-related peptide (cgrp) receptors and compromised responsiveness to cgrp of fetoplacental vessels in preeclamptic pregnancies." .

    "the big unanswered question is concerns over safety in pregnancy," she says. cgrp levels are lower than normal in pregnant women who have .